Hyaluronic acid fillers are typically stabilised by crosslinking with 1,4-butanediol diglycidyl ether (BDDE), to confer longevity. Otherwise, they would break down and eliminate within a week or two of injection.
The science behind Profhilo is fascinating. Prof. Chiara Schiraldi and Prof. Mario de Rosa developed the technology at the Second University of Naples. It is the first stabilised hyaluronic acid based product without the use of chemical cross-linking agents (BDDE). During the process, low and high molecular weight hyaluronic acid bond together using a patented completely chemical-free, thermal process that confers structural and rheologic stability.