If you’re exploring the latest innovations in aesthetic medicine, you’ve probably come across two buzzworthy treatments: exosomes and polynucleotides. Both are cutting-edge, regenerative skin treatments – but how do they compare? When it comes to exosomes vs polynucleotides, which is better?
Let’s dive into what each treatment involves, how they work, and what results you can expect – so you can make an informed, confident choice for your skin.
What is exosome treatment?
Exosomes are microscopic extracellular vesicles (tiny messengers) that your cells naturally produce. Think of them as biological couriers – they carry essential growth factors, proteins, and genetic material between cells, encouraging healing and regeneration.
Exosome treatment involves using exosomes from stem cells either on their own or in combination with procedures like microneedling or CO2 laser. Once applied to the skin, they get to work:
- Stimulating collagen and elastin production
- Reducing inflammation
- Improving skin hydration.
Exosome treatment can effectively address a wide range of skin concerns like fine lines, wrinkles, uneven texture or tone, redness and inflammation, pigmentation, and acne scarring. Exosome treatment can also be used for hair restoration.
Exosomes are especially loved for their ability to boost the skin’s natural regenerative capacity without introducing any heavy synthetics or chemicals.
At Health & Aesthetics, we use the Purasomes range from DermaFocus.
What are polynucleotide treatments?
Polynucleotides are another powerful tool in regenerative aesthetics, but they work a little differently. Polynucleotides are long chains of nucleotides (the building blocks of DNA). When injected into the skin, polynucleotides act as bio-stimulators – they actively encourage tissue repair, encourage cell growth and turnover, hydrate the skin, and boost skin elastin and collagen. They also create a healthier skin environment at a cellular level.
The key benefits of polynucleotide treatments include
- Reduced fine lines and wrinkles
- Smoother, firmer skin over time
- Improved skin hydration and overall skin health
- Reduced scarring and pigmentation.
Learn more about polynucleotide treatments.
Polynucleotides are incredibly gentle but effective – they’re quickly becoming a top choice for delicate areas like the under-eyes and the neck.
Exosomes vs polynucleotides: which is better?
If you’re trying to decide between exosomes vs polynucleotides, understanding their similarities and differences can really help. While both treatments fall under the umbrella of regenerative aesthetics – meaning they help the skin heal and renew itself naturally – they do so in slightly different ways, with different sources, mechanisms, and ideal use cases.
Similarities between exosomes and polynucleotides include:
- Regenerative benefits: Both treatments enhance the skin’s natural regeneration process. Rather than simply filling or freezing lines, they encourage healthier skin from within, making them ideal for long-term skin health.
- Minimally invasive: Neither treatment requires surgery or extensive downtime, making them suitable for clients who want subtle, natural-looking results with minimal disruption.
- Improves skin quality: Both treatments aim to improve overall skin texture, tone, hydration, and elasticity. Over time, you can expect smoother, firmer, and more radiant skin, helping to minimise signs of ageing and treat a range of skin concerns like scarring or pigmentation.
- Excellent for most skin types: They’re safe and effective for most skin tones and types, including sensitive or mature skin, and are often recommended as part of a maintenance or preventative skincare plan.
The key differences between exosomes and polynucleotides
| Exosomes | Polynucleotides | |
| Origin | Derived from stem cells | Derived from purified salmon or trout DNA (which is highly compatible with human DNA) |
| Main function | Acts as a communicator to send regenerative signals between cells | Acts as a building block, repairing damaged cells and improving tissue quality |
| Delivery | Applied topically, usually following a treatment like microneedling | Injected into the skin |
So, exosomes or polynucleotides, which is right for you?
Ultimately the right treatment depends on your needs. While exosomes and polynucleotides share similarities, they can target slightly different needs. During a medical consultation prior to treatment, our experts can assess your unique skin concerns and goals and recommend the right treatment based on your needs.
Both exosomes and polynucleotides are often used alongside other non-surgical treatments. It’s also common to have a combination of polynucleotides and exosomes together, using exosomes to support post-treatment healing and polynucleotides to nourish and hydrate and nourish over time. When used together under the guidance of an experienced practitioner, the results can be incredibly effective.
Finding the right treatment for you
If you’re curious about regenerative skin treatments like exosomes or polynucleotides, and want to explore how they can support your skin, book a consultation with our experienced team. We’re here to guide you every step of the way, with trusted advice and a professional approach.
